SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2; global transcription activator SNF2L2; ATP-dependent helicase SMARCA2; SNF2-alpha; protein brahma homolog; hBRM; BRG1-associated factor 190B; BAF190B (SMARCA2, BAF190B, BRM, SNF2A, SNF2L2)

Function

• transcriptional coactivator
• cooperates with nuclear hormone receptors to potentiate transcriptional activation
• also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex
• phosphorylated upon DNA damage, probably by ATM or ATR
• component of the BAF complex
• component of the npBAF complex & the nBAF complex, stem/progenitor & post-mitotic chromatin remodeling complexes
• component of the WINAC complex
• binds TOPBP1
• interacts with PHF10/BAF45A (putative)

Structure

• belongs to the SNF2/RAD54 helicase family
• contains 1 bromo domain
• contains 1 helicase ATP-binding domain
• contains 1 helicase C-terminal domain
• contains 1 HSA domain

Compartment

nucleus

Alternative splicing

named isoforms=2; long, short

More general terms

• SWI/SNF-related matrix-associated actin dependent regulator of chromatin subfamily A
• phosphoprotein

Component of

• npBAF complex (neural progenitors-specific chromatin remodeling complex)
• nBAF complex (neuron-specific chromatin remodeling complex)
• SWI/SNF-A (BAF) chromatin remodeling complex
• WINAC complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6595
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6595
• OMIM: https://mirror.omim.org/entry/600014
• UniProt: http://www.uniprot.org/uniprot/P51531.html