SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1; SWI/SNF complex 60 kD subunit; 60 kD BRG-1/Brm-associated factor subunit A; BRG1-associated factor 60A; BAF60A (SMARCD1, BAF60A)

Function

• role in chromatin remodeling
• component of the BAF complex
• component of npBAF complex & nBAF complex, involved in a switch from a neural stem/progenitord to post-mitotic neurons
• component of the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor
• strong influence on the vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element (VDRE)
• may be a link between mammalian SWI-SNF-like chromatin remodeling complexes & the vitamin D receptor heterodimer
• mediates interactions between nuclear receptors & the BRG1/SMARCA4 chromatin-remodeling complex for transactivation

Structure

• belongs to the SMARCD family
• contains 1 SWIB domain

Compartment

nucleus (probable)

Alternative splicing

named isoforms=2

Expression

• expressed in all tissues tested, including brain, heart, kidney, liver, lung, muscle, pancreas & placenta

More general terms

• SWI/SNF-related matrix-associated actin dependent regulator of chromatin subfamily D
• BRG1 associated factor
• nuclear protein

Component of

• SWI/SNF-A (BAF) chromatin remodeling complex
• npBAF complex (neural progenitors-specific chromatin remodeling complex)
• nBAF complex (neuron-specific chromatin remodeling complex)
• WINAC complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6602
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6602
• OMIM: https://mirror.omim.org/entry/601735
• UniProt: http://www.uniprot.org/uniprot/Q96GM5.html