actin-like protein 6A; 53 kD BRG1-associated factor A; actin-related protein Baf53a; ArpNbeta; BRG1-associated factor 53A; BAF53A; INO80 complex subunit K (ACTL6A, BAF53, BAF53A, INO80K)

Function

• role in transcriptional activation & repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology)
• required for maximal ATPase activity of SMARCA4 & for association of the SMARCA4-containing remodeling BAF complex with chromatin/nuclear matrix
• component of the npBAF complex & is required for the proliferation of neural progenitors
• component of the NuA4 histone acetyltransferase complex (HAT complex)
• also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex
• component of numerous complexes with chromatin remodeling & histone acetyltransferase activity
• component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 & YEATS4/GAS41
• component of the BAF complex
• component of the BAF53 complex
• component of the chromatin-remodeling INO80 complex
• component of the WINAC complex
• component of the npBAF complex
• interacts with PHF10/BAF45A (putative)

Structure

belongs to the actin family

Compartment

nucleus

Alternative splicing

named isoforms=2

More general terms

• cytoskeletal protein
• nuclear protein
• phosphoprotein

Component of

• NuA4 histone acetyltransferase (HAT) complex
• nBAF complex (neuron-specific chromatin remodeling complex)
• WINAC complex
• SWI/SNF-A (BAF) chromatin remodeling complex
• BAF53 complex
• INO80 complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=86
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:86; -.
• OMIM: https://mirror.omim.org/entry/604958
• UniProt: http://www.uniprot.org/uniprot/O96019.html