bromodomain-containing protein 8 (p120, skeletal muscle abundant protein, thyroid hormone receptor coactivating protein 120kD, TrCP120, BRD8, SMAP)

Function

• may act as a coactivator during transcriptional activation by hormone-activated nuclear receptors
• isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 & THRB/ERBA2
• at least isoform 1 & isoform 2 are components of the NuA4 histone acetyltransferase (HAT complex)
• BRD8 isoform 2 interacts with RXRA/NR2B1 & THRB/ERBA2
• phosphorylated on Thr-264, Ser-268 & Ser-284
• phosphorylated on Thr-124, Ser-128 & Ser-144
• phosphorylated on Thr-264, Ser-268 & Ser-284

Structure

contains 2 bromo domains

Compartment

nucleus

Expression

• expressed in adipose tissue, brain, heart, kidney, liver, lung, pancreas, placenta & skeletal muscle

Notes

uncertain whether Met-1 or Met-32 is the initiator

More general terms

• protein subunit

Component of

• NuA4 histone acetyltransferase (HAT) complex

Database

• OMIM: https://mirror.omim.org/entry/602848
• UniProt: http://www.uniprot.org/uniprot/Q9H0E9.html