YL1 tumor suppressor protein (vacuolar protein sorting protein 72, transcription factor-like 1, protein YL-1, VPS72, TCFL1, YL1)

Function

• DNA-binding transcriptional regulator
• chromatin modification & remodeling (putative)
• phosphorylated upon DNA damage, probably by ATM or ATR
• component of the NuA4 histone acetyltransferase complex
• also part of a multiprotein complex which contains SRCAP & binds H2AFZ

Structure

belongs to the VPS72/YL1 family

Compartment

nucleus

More general terms

• anti-oncoprotein (tumor suppressor protein)
• DNA-binding protein
• phosphoprotein

Component of

• NuA4 histone acetyltransferase (HAT) complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6944
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6944
• OMIM: https://mirror.omim.org/entry/600607
• UniProt: http://www.uniprot.org/uniprot/Q15906.html