Helicase SRCAP (Snf2-related CBP activator, domino homolog 2, SRCAP, KIAA0309)

Function

• catalytic component of the SRCAP complex
• acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, & Notch-mediated transcription
• interacts with CREBBP & EP300
• may be part of a complexcontaining SRCAP, CREBBP, CARM1 & GRIP1
• interacts with hepatitis C virus (HCV) NS5A & human adenovirus 2 DBP
• phosphorylated upon DNA damage, probably by ATM or ATR

Kinetic parameters:

• KM=66 uM for ATP

Structure

• belongs to the SNF2/RAD54 helicase family, SWR1 subfamily
• contains 3 A.T hook DNA-binding domain
• contains 1 helicase ATP-binding domain
• contains 1 helicase C-terminal domain
• contains 1 HSA domain

Compartment

nucleus

Alternative splicing

named isoforms=3

More general terms

• phosphoprotein
• helicase (DNA unwinding protein, DNA untwisting protein)

Database

• UniProt: http://www.uniprot.org/uniprot/Q6ZRS2.html