nonstructural protein 5A (NS5A)
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Function
- plays a key role in Hepatitis C virus RNA replication
Structure
- zinc-binding
- proline-rich hydrophilic
- phosphoprotein
Pharmacology
- NS5A inhibitor (velpatasvir) used in combination with sofosbuvir for treatment of hepatitis C infection
More general terms
References
- ↑ Wikipedia: NS5A https://en.wikipedia.org/wiki/NS5A
- ↑ Orciari Herman A, Fairchild DG] New Once-Daily Hepatitis C Pill Effective Across 6 Genotypes. Physician's First Watch, Nov 16, 2015 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org
Foster GR, Afdhal N, Roberts SK et al Sofosbuvir and Velpatasvir for HCV Genotype 2 and 3 Infection. N Eng J Med. November 17, 2015 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26575258 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMoa1512612
Ward JW, Mermin JH Simple, Effective, but Out of Reach? Public Health Implications of HCV Drugs. N Eng J Med. November 17, 2015 PMID: https://www.ncbi.nlm.nih.gov/pubmed/26575359