Histone-arginine methyltransferase CARM1; protein arginine N-methyltransferase 4; coactivator-associated arginine methyltransferase 1 (CARM1, PRMT4)

Function

• methylates guanidino nitrogens of Arg in
  • histone H3
  • EP300/P300
  • PABP1
• regulation of gene expression
• chromatin remodeling
• regulation of skeletal muscle differentiaton
• inhibits CREB-dependent transcription
• p53/TP53 transcriptional activation

Compartment

nucleus, cytoplasm

Pathology

• overexpressed in prostate adenocarcinomas & high-grade prostatic intraepithelial neoplasia.

More general terms

• N-methyltransferase
• nuclear protein

Additional terms

• prostate cancer

Component of

• Set1/Ash2 histone methyltransferase (HMT) complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10498
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10498
• OMIM: https://mirror.omim.org/entry/603934
• UniProt: http://www.uniprot.org/uniprot/Q86X55.html