E1A-binding protein p400; EC=3.6.4.-; CAG repeat protein 32; domino homolog; hdomino; trinucleotide repeat-containing gene 12 protein; p400 kD SWI2/SNF2-related protein (EP400, CAGH32, KIAA1498, KIAA1818, TNRC12)

Function

• component of the NuA4 histone acetyltransferase complex
• the NuA4 complex ATPase & helicase activities seem to be, at least in part, contributed by the association of RUVBL1 & RUVBL2 with EP400
• may regulate ZNF42 transcription activity
• may also participate in the formation of NuA4 related complexes which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP
• EP400 interacts with TRRAP, RUVBL1 & RUVBL2
• interacts with ZNF42
• interacts with PHF5A (putative)

Structure

• belongs to the SNF2/RAD54 helicase family, SWR1 subfamily
• contains 1 helicase ATP-binding domain
• contains 1 helicase C-terminal domain
• contains 1 HSA domain
• contains 1 Myb-like domain

Compartment

nucleus (putative)

Alternative splicing

named isoforms=5

Expression

ubiquitously expressed

More general terms

• protein subunit
• phosphoprotein
• DEAD box ATP-dependent helicase

Component of

• NuA4 histone acetyltransferase (HAT) complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=57634
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:57634
• OMIM: https://mirror.omim.org/entry/606265
• UniProt: http://www.uniprot.org/uniprot/Q96L91.html