YEATS domain-containing protein 4 (glioma-amplified sequence-41, Gas41, NuMA binding protein 1, NuBI-1, NuBI1, YEATS4, GAS41)

Function

• component of the NuA4 histone acetyltransferase (HAT complex)
• component of numerous complexes with chromatin remodeling & histone acetyltransferase activity
• component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, TCFL1/YL1 & YEATS4/GAS41
• YEATS4 interacts with MLLT10/AF10
• YEATS4 may also interact with the SWI/SNF component SMARCB1/BAF47, TACC1 & TACC2, & the nuclear matrix protein NUMA1

Structure

contains 1 YEATS domain

Compartment

nucleus

Expression

• expressed in brain, heart, kidney, liver, lung, pancreas, placenta & skeletal muscle

More general terms

• protein subunit

Component of

• NuA4 histone acetyltransferase (HAT) complex

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8089
• OMIM: https://mirror.omim.org/entry/602116
• UniProt: http://www.uniprot.org/uniprot/O95619.html