protein AF-10 (myeloid/lymphoid or mixed lineage leukemia translocated to 10, MLLT10, ALL1 fused gene from chromosome 10 protein, AF10)
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Structure
- contains 2 PHD-type zinc fingers
Compartment
Expression
expressed abundantly in testis
Pathology
- chromosomal translocation t(10;11)(p12;q23) involving MLLT10 with MLL/HRX is associated with acute leukemias
- result is a rogue activator protein
- chromosomal translocation t(10;11)(p13;q14) involving MLLT10 with PICALM is associated with diffuse histiocytic lymphomas
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P55197.html
- ↑ Atlas of Genetics and Cytogenetics in Oncology and Haematology http://atlasgeneticsoncology.org/Genes/AF10.html