nuclear mitotic apparatus protein 1; NuMA protein; SP-H antigen (NUMA1 NUMA)

Function

• cell cycle related protein
• essential for mitotic spindle formation
• may be a structural component of the nucleus
• C-terminal fragment interacts with importin beta

Compartment

• nucleus
• dissociates from condensing chromosomes during early prophase, before the complete disintegration of the nuclear lamina
• reassociates with telophase chromosomes very early during nuclear reformation, before substantial accumulation of lamins on chromosomal surfaces is evident

Alternative splicing

named isoforms=2

Pathology

• chromosomal translocation with retinoic acid gene
• DNA binding domains of RARA fused to 5' exons of NuMA in rare cases of acute promyelocytic leukemia

More general terms

• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4926
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4926
• OMIM: https://mirror.omim.org/entry/164009
• UniProt: http://www.uniprot.org/uniprot/Q14980.html