lamin or nuclear lamin
Jump to navigation
Jump to search
Function
- lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope & may also interact with chromatin
- structural integrity of lamins & the nuclear lamina is cell cycle dependent, with disintegration of the nuclear envelope in prophase & reformation in telophase
- increased phosphorylation of the lamins occurs before nuclear envelope disintegration & probably plays a role in regulating lamin associations
Laboratory
More general terms
- nuclear membrane protein
- intermediate filament protein
- phosphoprotein
- prenyl protein
- oligomerizing protein
More specific terms
References
- ↑ Holtz D et al The CaaX motif of lamin A functions in conjunction with the nuclear localization signal to target assembly to the nuclear envelope. Cell 59:969 1989 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2557160
- ↑ Alperts et al Molecular Biology of the Cell, Garland Publishing, New York, NY 1989 pg 662