SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1; BRG1-associated factor 57; BAF57 (SMARCE1, BAF57)

Function

• role in transcriptional activation & repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology)
• component of the BAF complex
• component of npBAF complex & nBAF complex, involved in a switch from a neural stem/progenitord to post-mitotic neurons
• association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor
• required for coactivation of estrogen responsive promoters by Swi/Snf complexes & the SRC/p160 family of histone acetyltransferases (HATs)
• specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells
• component of multiprotein chromatin-remodeling complexes:
  • Swi/Snf-A complex (BAF complex)
  • Swi/Snf-B complex (PBAF complex)
  • Brm complex
  • Brg1(I) complex
  • WINAC complex
  • Brg1(II) complex
• binds to the SRC/p160 family of histone acetyltransferases composed of NCOA1, NCOA2, & NCOA3

Structure

• HMG domain is essential for CD4 silencing & CD8 activation; mutation of this domain blocks thymus development
• contains 1 HMG box DNA-binding domain

Compartment

nucleus

Alternative splicing

named isoforms=2

More general terms

• SWI/SNF-related matrix-associated actin dependent regulator of chromatin subfamily E
• phosphoprotein
• nuclear protein

Component of

• SWI/SNF-A (BAF) chromatin remodeling complex
• npBAF complex (neural progenitors-specific chromatin remodeling complex)
• nBAF complex (neuron-specific chromatin remodeling complex)
• WINAC complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6605
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6605
• OMIM: https://mirror.omim.org/entry/603111
• UniProt: http://www.uniprot.org/uniprot/Q969G3.html