SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3; 60 kD BRG-1/Brm-associated factor subunit C; BRG1-associated factor 60C; BAF60C (SMARCD3, BAF60C)

Function

• role in ATP dependent nucleosome remodeling by SMARCA4 containing complexes
• stimulates nuclear receptor mediated transcription
• component of the BAF complex
• component of npBAF complex & nBAF complex, involved in a switch from a neural stem/progenitord to post-mitotic neurons
• interacts with SMARCA4/BRG1/BAF190A, the catalytic subunit of the SWI/SNF related nucleosome-remodeling complexes BRG1(I) & BRG1(II)
• also interacts with several nuclear receptors including PPARG/NR1C3, RXRA/NR1F1, ESR1, NR5A1/SF1, NR5A2/LRH1 & other transcriptional activators including the HLH protein SREBF1/SREBP1 & the homeobox protein PBX1
• may allow recruitment of Swi/SNF containing complexes specifically to promoters where these factors are located

Structure

• belongs to the SMARCD family
• contains 1 SWIB domain

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• isoform 2 & isoform 1 are expressed in brain, heart, kidney, placenta, prostate, salivary gland, spleen, testis, thyroid, trachea & uterus
• isoform 1 is also expressed in skeletal muscle & adipose tissue

More general terms

• SWI/SNF-related matrix-associated actin dependent regulator of chromatin subfamily D
• BRG1 associated factor
• nuclear protein
• phosphoprotein

Component of

• SWI/SNF-A (BAF) chromatin remodeling complex
• npBAF complex (neural progenitors-specific chromatin remodeling complex)
• nBAF complex (neuron-specific chromatin remodeling complex)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6604
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6604
• OMIM: https://mirror.omim.org/entry/601737
• UniProt: http://www.uniprot.org/uniprot/Q6STE5.html