zinc finger MIZ domain-containing protein 2; PIAS-like protein Zimp7 (ZMIZ2, KIAA1886, ZIMP7, HRIHFB2007)

Function

• increases ligand-dependent transcriptional activity of AR & other nuclear hormone receptors
• interacts with AR, SMARCA4/BRG1 & SMARCE1/BAF57
• interaction with either SMARCA4 or SMARCE1 enhances AR-mediated transcription

Structure

• C-terminal proline-rich domain has intrinsic transcriptional activity that is inhibited by N-terminus in the full-length protein
• contains 1 SP-RING-type zinc finger

Compartment

• nucleus
• detected at replication foci throughout S phase

Alternative splicing

named isoforms=3

Expression

• expressed in testis > heart, brain, pancreas, prostate, ovary

More general terms

• ring finger protein
• transcription factor (TF)

Database

• UniProt: http://www.uniprot.org/uniprot/Q8NF64.html