cyclin E1 (CCNE1)
Jump to navigation
Jump to search
Function
- essential for the control of the cell cycle at the G1/S (start) transition
- interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex
- the cyclin subunit imparts substrate specificity to the complex
- interacts with retinoblastoma-binding protein 3 & retinoblastoma-like protein 1
- found in a complex with CDK2, CABLES1 & CCNA1
- part of a complex consisting of UHRF2, CDK2 & CCNE1
- phosphorylation of Thr-395 by GSK3 & of Ser-399 by CDK2 accelerates degradation via the ubiquitin proteasome pathway phosphorylated upon DNA damage, probably by ATM or ATR
Structure
belongs to the cyclin family, cyclin E subfamily
Compartment
nucleus Alternative
- splicing, named isoforms=2
- lacks 49 residues within the cyclin box & cannot complex with CDK2
Expression
- highly expressed in testis & placenta
- low levels in bronchial epithelial cells
- G1 cyclin of fibroblasts
- G1/S-specific E1
- expression under transcriptional control[2]
More general terms
Additional terms
References
- ↑ Dulie V, Lees E, Reed SI. Association of human cyclin E with a periodic G1-S phase protein kinase. Science. 1992 Sep 25;257(5078):1958-61. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1329201
- ↑ 2.0 2.1 Morgan DO. Principles of CDK regulation. Nature. 1995 Mar 9;374(6518):131-4. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7877684
- ↑ UniProt http://www.uniprot.org/uniprot/P24864.html