cyclin A1 (CCNA1)

Function

• may be involved in the control of the cell cycle at the G1/S (start) & G2/M (mitosis) transitions
• may primarily function in the control of the germline meiotic cell cycle & additionally in the control of mitotic cell cycle in some somatic cells
• interacts with the CDK2 & the CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex
• the cyclin subunit imparts substrate specificity to the complex
• does not bind CDK4 & CDK5 (in vitro)
• the cyclin A1-CDK2 complex interacts with transcription factor E2F-1 & RB proteins
• found in a complex with CDK2, CABLES1 & CCNE1 (putative)
• interacts with KLHDC9

Structure

• belongs to the cyclin family, cyclin AB subfamily

Expression

• very high levels in testis & very low levels in brain
• expression increases in early G1 phase & reaches highest levels during the S & G2/M phases

Pathology

found in myeloid Leukemia cell lines

More general terms

• cyclin A

Component of

• CDK1/cyclin-A complex

Database

• UniProt: http://www.uniprot.org/uniprot/P78396.html
• OMIM: https://mirror.omim.org/entry/604036
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8900