POU domain, class 2, transcription factor 1; NF-A1; octamer-binding protein 1; Oct-1; octamer-binding transcription factor 1; OTF-1 (POU2F1, OCT1, OTF1)

Function

• transcription factor & DNA-binding protein
• one of several proteins that bind to same octamer DNA sequence
• binds to the octamer motif 5'-ATTTGCAT-3' & activates promoters of genes for some small nuclear RNAs (snRNA) & of genes such as those for histone H2B & immunoglobulins
• modulates transcription transactivation by NR3C1, AR & PGR (putative)
• interacts with NR3C1, AR, PGR & HCFC1
• phosphorylated by PRKDC

Structure

• belongs to the POU transcription factor family, class- 2 subfamily
• contains 1 homeobox DNA-binding domain
• contains 1 POU-specific domain

Compartment

nucleus

Alternative splicing

named isoforms=4

Expression

• ubiquitous in mammalian cells
• isoform 2 is lymphocyte-specific

More general terms

• octamer transcription factor
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5451
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5451
• OMIM: https://mirror.omim.org/entry/164175
• UniProt: http://www.uniprot.org/uniprot/P14859.html