heterogeneous nuclear ribonucleoprotein U-like protein 1; adenovirus early region 1B-associated protein 5; E1B-55 kDa-associated protein 5; E1B-AP5 (HNRNPUL1, E1BAP5)

Function

• general transcriptional regulator
• represses general transcription driven by several virus & cellular promoters
• activates transcription of glucocorticoid-responsive promoter in the absence of ligand stimulation in association with BRD7
• mRNA processing & transport
• binds avidly to poly(G) & poly(C) RNA homopolymers in vitro
• interacts with the adenovirus type 5 (Ad5) E1B-55 kD, BRD7, HRMT1L1, TP53 & TAP
• associates with histones & BRD7

Structure

• methylated
  • RGG-box domain is methylated.
  • methylation enhanced in late phase of adenoviral infection
• contains 1 SPRY domain
• contains 1 SAP domain

Compartment

nucleus

Alternative splicing

named isoforms=5

More general terms

• phosphoprotein
• heterogeneous nuclear ribonucleoprotein (hnRNP)

Database

• OMIM: https://mirror.omim.org/entry/605800
• UniProt: http://www.uniprot.org/uniprot/Q9BUJ2.html