interferon regulatory factor 2 (IRF2)
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Function
- specifically binds to the upstream regulatory region of type 1 IFN & IFN-inducible MHC class 1 genes (the interferon consensus sequence, ICS) & represses those genes
- interacts with BRD7, IRF2BP1 & IRF2BP2
Structure
- belongs to the IRF family
- contains 1 tryptophan pentad repeat DNA-binding domain
Compartment
Expression
induced by viruses & IFN