interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2, IRF-2BP2, IRF2BP2)

Function

• acts as a transcriptional repressor
• acts as a transcriptional corepressor (IRF2-dependent)
• repression is not mediated by histone deacetylase
• interacts with IRF2
• part of a corepressor complex containing IRF2 & IRF2BP1

Structure

• C-terminal RING-type Zn+2 finger domain is necessary for interaction with BAP1
• belongs to the IRF2BP family
• contains 1 RING-type Zn+2 finger

Compartment

nucleus

Alternative splicing

named isoforms=3

More general terms

• transcriptional silencer (transcriptional repressor)
• ring finger protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q7Z5L9.html