segment polarity protein dishevelled homolog DVL-1; dishevelled-1; DSH homolog 1 (DVL1)

Function

• may play a role in the signal transduction pathway mediated by multiple Wnt genes
• ubiquitinated, leading to its subsequent degradation by the ubiquitin-proteasome
• interaction with INVS is required for ubiquitination
• interacts with CXXC4
• interacts (via PDZ domain) with NXN (putative)
• interacts with BRD7 & INVS. interacts through its PDZ domain with the C-terminal regions of VANGL1, VANGL2 & CCDC88C/DAPLE
• interacts with ARRB1; the interaction is enhanced by
• phosphorylation of DVL1

Structure

• belongs to the DSH family
• contains 1 DEP domain
• contains 1 DIX domain
• contains 1 PDZ domain (DHR domain)

Compartment

cytoplasm (putative)

Alternative splicing

named isoforms=2

More general terms

• dishevelled family protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1855
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1855
• OMIM: https://mirror.omim.org/entry/601365
• UniProt: http://www.uniprot.org/uniprot/O14640.html