nucleoredoxin (NXN, NRX)

Function

• redox-dependent negative regulator of the Wnt signaling pathway
• may function as a transcriptional regulator
• may regulate phosphatase 2A (putative)
• associates with the phosphatase 2A holoenzyme
• interacts with PPP2CA; the interaction is direct
• interacts with DVL1 (via PDZ domain); the interaction is direct & regulated by oxidative stress (putative)

Structure

• belongs to the nucleoredoxin family
• contains 1 thioredoxin domain

Compartment

cytoplasm, cytosol (putative), nucleus

Alternative splicing

named isoforms=2

More general terms

• oxidoreductase

Database

• UniProt: http://www.uniprot.org/uniprot/Q6DKJ4.html