protein phosphatase 2 catalytic subunit alpha; phosphatase 2A catalytic subunit alpha isoform (PPP2CA)

Function

• reversibly methyl esterified on Leu-309
• carboxyl methylation may play a role in holoenzyme assembly varies during the cell cycle
• phosphorylation of either Thr (by autophosphorylation- activated protein kinase) or Tyr results in inactivation of the phosphatase
  • auto-dephosphorylation has been suggested as a mechanism for reactivation

a phosphoprotein + H2O <--> a protein + phosphate

Cofactor:

• binds 1 iron ion per subunit (putative)
• binds 1 Mn+2 per subunit (putative)

Structure

belongs to the PPP phosphatase family, PP-1 subfamily

Compartment

cytoplasm

More general terms

• phosphatase 2A catalytic subunit

Additional terms

• phosphatase-2A (ceramide-activated protein phosphatase)

Database

• UniProt: http://www.uniprot.org/uniprot/P67775.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5515
• OMIM: https://mirror.omim.org/entry/176915
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5515