transcription intermediary factor 1-alpha; TIF1-alpha; RING finger protein 82; tripartite motif-containing protein 24 (TRIM24, RNF82, TIF1, TIF1A)

Function

• interacts selectively in vitro with the AF2-activating domain of the estrogen receptors
• association with DNA-bound estrogen receptors requires the presence of estradiol
• phosphorylated upon DNA damage, probably by ATM or ATR
• interacts with CBX1 & CBX3 (putative)
• interacts with NR3C2

Structure

• contains 2 B box-type Zn+2 fingers
• contains 1 bromo domain
• contains 1 PHD-type Zn+2 finger
• contains 1 RING-type Zn+2 finger

Compartment

nucleus (putative)

Alternative splicing

named isoforms=2; long, short

Pathology

• defects in TRIM24 are a cause of thyroid papillary carcinoma
• translocation t(7;10)(q32;q11) with RET; translocation generates the TIF1/RET (PTC6) oncogene

More general terms

• DNA-binding protein
• ring finger protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8805
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8805
• OMIM: https://mirror.omim.org/entry/188550
• OMIM: https://mirror.omim.org/entry/603406
• UniProt: http://www.uniprot.org/uniprot/O15164.html