chromobox protein homolog 1; heterochromatin protein 1 homolog beta; HP1 beta; modifier 1 protein; M31; heterochromatin protein p25; HP1Hsbeta; p25beta (CBX1 CBX)

Function

• component of heterochromatin
• recognizes & binds histone H3 tails methylated at Lys-9, leading to epigenetic repression
• interaction with lamin B receptor (LBR) may contribute to association of heterochromatin with the inner nuclear membrane
• not phosphorylated
• interacts directly with CHAF1A, EMSY, LBR, TIF1/TIF1A & TRIM28/TIF1B PXVXL motif via the chromoshadow domain
• interacts directly with histone H3 methylated at Lys-9 via the chromo domain
• interacts with SUV39H1 & SETDB1, SUV420H1 & SUV420H2
• interacts with PRDM6

Structure

• homodimer
• contains 2 chromo domains

Compartment

• nucleus
• not associated with chromosomes during mitosis

Expression

In all adult & embryonic tissues

More general terms

• heterochromatin protein 1 homolog

Database

• UniProt: http://www.uniprot.org/uniprot/P83916.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10951
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10951
• OMIM: https://mirror.omim.org/entry/604511