histone-lysine N-methyltransferase SUV420H2; suppressor of variegation 4-20 homolog 2; Suv4-20h2; Su(var)4-20 homolog 2 (SUV420H2)
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Function
- histone methyltransferase
- specifically trimethylates Lys-20 of histone H4
- histone H4 Lys-20 trimethylation represents a specific tag for epigenetic transcriptional repression
- mainly functions in pericentric heterochromatin regions, & plays role in establishment of constitutive heterochromatin in these regions
- SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 & RBL2)
- interacts with HP1 proteins CBX1, CBX3 & CBX5
S-adenosyl-L-methionine + histone L-lysine
<-->
S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine
Structure
- belongs to the histone-lysine methyltransferase family, Suvar4-20 subfamily
- contains 1 SET domain
Compartment
- nucleus
- associated with pericentric heterochromatin
- CBX1 & CBX5 are required for localization to pericentric heterochromatin
Alternative splicing
named isoforms=3