neutrophil defensin 1; defensin, alpha 1; HNP-1; HP-1; HP1; contains: neutrophil defensin 2 (DEFA1, DEF1, MRS, DEFA1B)

Function

• defensin 1 & defensin 2 have antibacterial, fungicide & antiviral activities
• defensin 2 apparently arises from cleavage of defensin 1 or defensin 3
• antimicrobial activity against Gram-negative & Gram-positive bacteria
• defensins are thought to kill microbes by permeabilizing their plasma membrane
• ADP-ribosylation drastically reduces cytotoxic & antibacterial activities, & enhances IL8 production
• phosphorylation at Tyr-85 has been found in some cancer cell lines, & interferes with ADP-rybosylation

Structure

• dimer
• belongs to the alpha-defensin family

Compartment

• found in microbicidal granules of neutrophils
• secreted

More general terms

• defensin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1667
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=728358
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1667
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:728358
• OMIM: https://mirror.omim.org/entry/125220
• UniProt: http://www.uniprot.org/uniprot/P59665.html