neutrophil defensin 3; defensin, alpha 3; HNP-3; HP-3; HP3; contains: neutrophil defensin 2; HNP-2; HP-2; HP2 (DEFA3, DEF3)

Function

• defensin 2 & defensin 3 have antibiotic, fungicide & antiviral activities
• defensin 2 apparently arises from cleavage of defensin 1 or defensin 3
• antimicrobial activity against Gram-negative & Gram-positive bacteria
• defensins are thought to kill microbes by permeabilizing their plasma membrane

Structure

• dimer
• belongs to the alpha-defensin family

Compartment

secreted

More general terms

• defensin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1668
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1668
• OMIM: https://mirror.omim.org/entry/604522
• UniProt: http://www.uniprot.org/uniprot/P59666.html