chromobox protein homolog 5; heterochromatin protein 1 homolog alpha; HP1 alpha; antigen p25 (CBX5 HP1A)

Function

• component of heterochromatin
• recognizes & binds histone H3 tails methylated at Lys-9, leading to epigenetic repression.
• interaction with lamin B receptor may contribute to association of heterochromatin with inner nuclear membrane
• role in formation of functional kinetochore through interaction with MIS12 complex proteins
• phosphorylation of HP1 & LBR may be responsible for some of the alterations in chromatin organization & nuclear structure which occur at various times during the cell cycle
• phosphorylated during interphase
• possibly hyper-phosphorylated during mitosis
• interacts with SUV420H1 & SUV420H2 (putative)
• interacts with HP1BP3 (putative)
• interacts directly with ATRX, CHAF1A, LBR, NIPBL, SP100, STAM2 & TRIM28 via the chromoshadow domain
• can interact directly with CBX3 via the chromoshadow domain
• interacts with histone H3 methylated at Lys-9
• interacts with BAHD1, MIS12 & DSN1

Structure

contains 2 chromo domains

Compartment

• nucleus, centromere
• component of centromeric & pericentromeric heterochromatin
• associates with chromosomes during mitosis
• associates specifically with chromatin during metaphase & anaphase

More general terms

• heterochromatin protein 1 homolog
• chromobox protein homolog
• antigen

Database

• UniProt: http://www.uniprot.org/uniprot/P45973.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23468
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23468
• OMIM: https://mirror.omim.org/entry/604478