signal transducing adapter molecule 2; STAM-2; Hrs-binding protein (STAM2, HBP)

Function

• role in intracellular signal transduction mediated by cytokines & growth factors
• upon IL-2 & GM-CSL stimulation, plays a role in signaling leading to DNA synthesis & MYC induction
• may also play a role in T-cell development
• role in down-regulation of receptor tyrosine kinase via multivesicular body when complexed with HGS (ESCRT-0 complex)
• phosphorylated in response to IL-2, GM-CSF, EGF & PDGF
• component of the ESCRT-0 complex
• interacts with JAK2 & JAK3
• interacts with ubiquitinated proteins & the deubiquitinating enzyme USP8/UBPY (putative)
• interacts (via the via the PxVxL motif) with CBX5
• interacts with VPS37C
• interacts with ubiquitin

Structure

• the VHS & UIM domains mediate the interaction with ubiquitinated proteins
• the SH3 domain mediates the interaction with USP8
• contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains
• this motif requires additional residues -7, -6, +4 & +5 of the central Val which contact the chromoshadow domain
• belongs to the STAM family
• contains 1 ITAM domain
• contains 1 SH3 domain
• contains 1 UIM (ubiquitin-interacting motif) repeat
• contains 1 VHS domain

Compartment

• cytoplasm (putative)
• early endosome membrane
• peripheral membrane, cytoplasmic side

Alternative splicing

named isoforms=2

Expression

ubiquitously expressed

More general terms

• phosphoprotein

Component of

• ESCRT-0 complex; STAM1/STAM2-HGS complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10254
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10254
• OMIM: https://mirror.omim.org/entry/606244
• UniProt: http://www.uniprot.org/uniprot/O75886.html