ubiquitin carboxyl-terminal hydrolase 8 (ubiquitin thioesterase 8, ubiquitin-specific-processing protease 8, deubiquitinating enzyme 8, hUBPy, USP8, KIAA0055, UBPY)

Function

• hydrolase that can remove conjugated ubiquitin from proteins
• regulatory role at the level of protein turnover by preventing degradation
• role in cell proliferation
• probably regulates the stability of STAM2 & RASGRF1
• required to enter into S phase in response to serum stimulation
• may regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 & STAM2
• forms a ternary complex with RNF128 & OTUB1
• interacts with the SH3 domain of STAM2
• interacts with RASGRF1 & RNF41

ubiquitin C-terminal thioester + H2O
          <-->
ubiquitin + a thiol

Structure

• belongs to the peptidase C19 family
• contains 1 rhodanese domain

Expression

• upon growth stimulation in starved human fibroblasts
• decreases in response to growth arrest induced by cell-cell contact

More general terms

• ubiquitin C-terminal hydrolase

Additional terms

• ubiquitin (UBCEP2, UBB, UBC)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9101
• OMIM: https://mirror.omim.org/entry/603158
• UniProt: http://www.uniprot.org/uniprot/P40818.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9101