E3 ubiquitin-protein ligase RNF128; RING finger protein 128; gene related to anergy in lymphocytes protein (RNF128, GRAIL)
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Function
- E3 ubiquitin-protein ligase, catalyzes formation of polyubiquitin chains
- inhibitor of cytokine gene transcription
- inhibits IL2 & IL4 transcription via E3 ligase activity
- induction of the anergic phenotyp
- patterning of dorsal ectoderm
- sensitizes ectoderm to neural-inducing signals
- ubiquitin conjugation, 3rd step
- induced under anergic conditions
- up-regulated during T cell anergy induction following signaling through the T cell antigen receptor
- binds to E2 ubiquitin-conjugating enzyme
- requires intact RING finger
- auto-ubiquitinated
- controls the development of T cell clonal anergy by ubiquitination
Structure
- contains 1 PA domain (protease associated) domain) contains 1 RING-type zinc finger
Compartment
- intracytoplasmic membrane, perinuclear region
- localized in an asymmetric perinuclear punctate manner
- localizes to the internal pool of the transferrin recycling endosomal pathway
- partially colocalized with endoplasmic reticulum resident HSPA5, with Golgi resident STX5, & with the late endosomal GTPase RAB7
Alternative splicing
named isoforms=2