syntaxin-5 (STX5, STX5A)

Function

• mediates endoplasmic reticulum to Golgi transport
• part of a ternary complex containing STX5A, NSFL1C & VCP
• identified in a unique SNARE complex composed of the Golgi SNAREs GOSR1, GOSR2 & YKT6 (putative)

Structure

• belongs to the syntaxin family
• contains 1 t-SNARE coiled-coil homology domain

Compartment

• endoplasmic reticulum-Golgi intermediate compartment membrane
• Golgi apparatus membrane

Alternative splicing

• alternative initiation
• named isoforms=3

Notes

• produced by alternative initiation at Met-55 of isoform 1
• produced by alternative initiation & alternative splicing

More general terms

• syntaxin

Component of

• Golgi SNARE complex (Golgi SNAP receptor complex)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6811
• OMIM: https://mirror.omim.org/entry/603189
• UniProt: http://www.uniprot.org/uniprot/Q13190.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6811