synaptobrevin homolog YKT6

Function

• vesicular soluble NSF attachment protein receptor (v-SNARE)
• mediates vesicle docking & fusion to a specific acceptor cellular compartment
• functions in endoplasmic reticulum to Golgi transport
• component of a SNARE complex containing GOSR1, GOSR2 & STX
• functions in early/recycling endosome to TGN transport, as part of a SNARE complex containing of BET1L, GOSR1 & STX5
• S-palmitoyl transferase
• component of 2 different SNARE complexes

Structure

• longin domain regulates palmitoylation & membrane targeting
• palmitoylated
  • catalyzes its own palmitoylation
  • palmitoylation is required for Golgi targeting
• farnesylation is required for Golgi targeting
• belongs to the synaptobrevin family
• contains 1 longin domain
• contains 1 v-SNARE coiled-coil homology domain

Compartment

• cytoplasm
• vesicle & Golgi membrane, lipid-anchor, cytoplasmic side
• probably cycles through vesicles between Golgi & endosomes

More general terms

• SNARE protein

Database

• OMIM: https://mirror.omim.org/entry/606209
• UniProt: http://www.uniprot.org/uniprot/O15498.html