N-ethylmaleimide [NEM]-sensitive fusion protein; vesicle-fusing ATPase; vesicular-fusion protein NSF (NSF)
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Function
- role in membrane fusion & vesicle trafficking
- required for vesicle-mediated transport
- catalyzes fusion of transport vesicles within the Golgi cisternae
- also required for transport from the endoplasmic reticulum to the Golgi stack
- seems to function as a fusion protein required for delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin
- interacts with GABARAP & GABARAPL2
Cofactor: binds 1 Mg+2 per subunit (putative)
Structure
- homohexamer
- belongs to the AAA ATPase family
- homolog of yeast SEC18 product
Compartment
More general terms
Additional terms
References
- ↑ Sollner T, Whiteheart SW, Brunner M et al SNAP receptors implicated in vesicle targeting and fusion. Nature. 1993 Mar 25;362(6418):318-24. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8455717
- ↑ Sheng M. Molecular organization of the postsynaptic specialization. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7058-61. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11416187
- ↑ UniProt http://www.uniprot.org/uniprot/P46459.html