gamma-aminobutyric acid receptor-associated protein-like 2; GABA(A) receptor-associated protein-like 2; ganglioside expression factor 2; GEF-2; general protein transport factor p16; Golgi-associated ATPase enhancer of 16 kD; GATE-16; MAP1 light chain 3-related protein (GABARAPL2, FLC3A, GEF2)

Function

• intra-Golgi traffic
• modulates intra-Golgi transport via coupling between NSF & SNAREs
• stimulates ATPase activity of NSF which in turn stimulates association with GOSR1
• phosphorylated upon DNA damage, probably by ATM or ATR
• interacts with GABRG2, NSF, GOSR1, beta-tubulin, ULK1
• interacts with TP53INP1 & TP53INP2
• interacts with TBC1D25

Structure

• monomer
• belongs to the MAP1 LC3 family

Compartment

• Golgi
• cytoplasmic vesicle, autophagosome

Expression

• ubiquitous
• expressed at high levels in the brain, heart, prostate, ovary, spleen, skeletal muscle
• expressed at very low levels in lung, thymus, small intestine

More general terms

• cytoskeletal protein

Additional terms

• GABA-A receptor
• gamma-aminobutyric acid receptor-associated protein; GABA(A) receptor-associated protein; MM46 (GABARAP, FLC3B, HT004)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11345
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11345
• OMIM: https://mirror.omim.org/entry/607452
• UniProt: http://www.uniprot.org/uniprot/P60520.html