ras guanine nucleotide releasing factor 1; Ras-specific guanine nucleotide-releasing factor 1; Ras-GRF1; guanine nucleotide-releasing factor 1; Ras-specific nucleotide exchange factor CDC25 (RASGRF1, CDC25, GNRP, GRF1)
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Introduction
Protein distinct from ras-GAP.
Function
- promotes the exchange of Ras-bound GDP by GTP
- catalyzes release of GTP from p21H-ras & p21N-ras.
- ubiquitinated (putative)
- homooligomer & heterooligomer with RASGRF2
- interacts with USP8, thereby regulating its stability (putative)
Structure
- may be related to CDC25 protein of Saccharomyces cerevisiae
- the DH (DBL-homology) domain mediates interaction with RASGRF2
- contains 1 DH (DBL-homology) domain
- contains 1 IQ domain
- contains 1 N-terminal Ras-GEF domain
- contains 2 PH domains
- contains 1 Ras-GEF domain
Alternative splicing
named isoforms=2
More general terms
Additional terms
References
- ↑ Wolfman A, Macara IG. A cytosolic protein catalyzes the release of GDP from p21ras. Science. 1990 Apr 6;248(4951):67-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2181667
- ↑ Marx Science 251:484 1992
- ↑ Shou C, Farnsworth CL, Neel BG, Feig LA. Molecular cloning of cDNAs encoding a guanine-nucleotide- releasing factor for Ras p21. Nature. 1992 Jul 23;358(6384):351-4. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1379346
- ↑ Chardin P, Camonis JH, Gale NW, van Aelst L, Schlessinger J, Wigler MH, Bar-Sagi D. Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science. 1993 May 28;260(5112):1338-43. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8493579
- ↑ Boguski MS & McCormick F Proteins regulating Ras and its relative. Nature 366:643 1993 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8259209
- ↑ UniProt http://www.uniprot.org/uniprot/Q13972.html
- ↑ Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/RASGRF1ID43453ch15q25.html