lamin-B receptor; integral nuclear envelope inner membrane protein; LMN2R (LBR)

Function

• anchors the lamina & the heterochromatin to the inner nuclear membrane
• interacts directly with CBX5
• can interact with chromodomain proteins
• interacts directly with DNA
• interaction with DNA is sequence independent with higher affinity for supercoiled & relaxed circular DNA than linear DNA
• phosphorylated by CDC2 protein kinase in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina & the chromatin.
• phosphorylated by different protein kinases in interphase when the membrane is associated with these structures
• phosphorylation of LBR & HP1 proteins may be responsible for some of the alterations in chromatin organization & nuclear structure which occur at various times during the cell cycle

Structure

belongs to the ERG4/ERG24 family

Compartment

nucleus inner membrane

Pathology

• defects in LBR are a cause of
  • Pelger-Huet anomaly
  • Greenberg skeletal dysplasia

More general terms

• nuclear protein
• receptor
• phosphoprotein
• transmembrane 8 protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3930
• OMIM: https://mirror.omim.org/entry/169400
• OMIM: https://mirror.omim.org/entry/215140
• OMIM: https://mirror.omim.org/entry/600024
• UniProt: http://www.uniprot.org/uniprot/Q14739.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=