chromobox protein homolog 3; heterochromatin protein 1 homolog gamma; HP1 gamma; modifier 2 protein; HECH (CBX3)

Function

• component of heterochromatin
• seems to be involved in transcriptional silencing in heterochromatin-like complexes
• recognizes & binds histone H3 tails methylated at Lys-9, leading to epigenetic repression
• may contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor
• role in formation of functional kinetochore through interaction with MIS12 complex proteins
• phosphorylated by PIM1
• phosphorylated during interphase
• possibly hyper-phosphorylated during mitosis
• binds directly to CHAF1A
• interacts with histone H3 methylated at Lys-9
• part of the E2F6.com-1 complex
• interacts with LBR, INCENP, TRIM28/TIF1B, SUV420H1, SUV420H2 & SP100
• interacts with TIF1A (putative)
• interacts with MIS12 & DSN1
• can interact directly with CBX5 via the chromoshadow domain

Structure

contains 2 chromo domains

Compartment

• nucleus (putative)
• associates with euchromatin & is largely excluded from constitutive heterochromatin
• may be associated with microtubules & mitotic poles during mitosis (putative)

More general terms

• heterochromatin protein 1 homolog

Component of

• E2F6.com-1 complex

Database

• UniProt: http://www.uniprot.org/uniprot/Q13185.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11335
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11335
• OMIM: https://mirror.omim.org/entry/604477