inner centromere protein (INCENP)

Function

• component of the chromosomal passenger complex
• probably acts through association with AURKB or AURKC
• seems to bind directly to microtubules
• controls the kinetochore localization of BUB1
• phosphorylation by AURKB at its C-terminal part is important for AURKB activation by INCENP
• interacts with H2AFZ
• interacts with CBX3
• interacts with tubulin beta chain
• interacts with AURKB & AURKC
• interacts with EVI5. interacts with CDCA8 & BIRC5
• interacts with CBX5
  • POGZ & INCENP compete for interaction with CBX5
• interacts with POGZ
• interacts with JTB

Structure

• homodimer or heterodimer
• belongs to the INCENP family

Compartment

• chromosome, centromere
• cytoplasm, cytoskeleton, spindle
• nucleus. chromosome, centromere, kinetochore
• ocalizes to inner kinetochore
• localizes on chromosome arms & inner centromeres from prophase through metaphase & then transferring to the spindle midzone & midbody from anaphase through cytokinesis
• colocalizes with AURKB at mitotic chromosomes

Alternative splicing

named isoforms=2

More general terms

• centromere protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3619
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3619
• OMIM: https://mirror.omim.org/entry/604411
• UniProt: http://www.uniprot.org/uniprot/Q9NQS7.html