borealin (Dasra-B, hDasra-B, cell division cycle-associated protein 8, pluripotent embryonic stem cell-related gene 3 protein, CDCA8, PESCRG3)

Function

• component of the chromosomal passenger complex (CPC)
  • in the complex, directs CPC to centromeric DNA (putative)
• cell-cycle regulated, increases during G2/M phase, diminishes after exit from M phase
• mediates phosphorylation of Ser-10 of histone H3 (putative)

Structure

may form homooligomers

Compartment

• nucleus, nucleolus, cytoplasm
• localizes on chromosome arms & inner centromeres from prophase through metaphase, transfers to spindle midzone & midbody from anaphase through cytokinesis

Expression

• cell-cycle regulated
• increases during G2/M phase & then reduces after exit from M phase

More general terms

• nuclear protein
• phosphoprotein

Component of

• chromosome passenger complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55143
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55143
• OMIM: https://mirror.omim.org/entry/609977
• UniProt: http://www.uniprot.org/uniprot/Q53HL2.html