chromosome passenger complex

Function

• acts as a key regulator of mitosis
• essential functions at the centromer
  • ensures correct chromosome alignment & segregatio
  • required for chromatin-induced microtubule stabilization & spindle assembly

Structure

• consists of:
  • AURKB/aurora-B, BIRC5/survivin, CDCA8/borealin, INCENP

More general terms

• molecular complex
• nuclear protein