chromosomal passenger complex (CPC)

Function

• regulator of mitosis
• functions at the centromere in ensuring correct chromosome alignment & segregation
• required for chromatin-induced microtubule stabilization & spindle assembly
• cells lacking CDCA8 display a slight decrease in histone H3 Ser-10 phosphorylation, suggesting that the CPC complex mediates phosphorylation of Ser-10 of histone H3

Structure

• subunits:
  • BIRC5/survivin, CDCA8/borealin, INCENP & AURKB/Aurora-B

More general terms

• molecular complex