Aurora-related kinase 3; Aurora kinase C; Aurora/IPL1-related kinase 3; ARK-3; serine/threonine protein kinase 13; Aurora/IPL1/Eg2 protein 2; serine/threonine protein kinase aurora-C (AURKC, AIE2, AIK3, ARK3, STK13)

Function

• may play a role in organizing microtubules for the centrosome/spindle pole during mitosis
• may contribute to regulation of chromosome segregation & cytokinesis

Structure

• belongs to the protein kinase superfamily, Ser/Thr protein kinase family, Aurora subfamily
• contains 1 protein kinase domain

Compartment

• chromosome, cytoplasm, cytoskeleton, spindle
• distributes in the condensed chromosomes during prophase to metaphase
• after entering anaphase, dissociates from separated chromosomes & a redistributes to midzone microtubules
• remains in the midbody during cytokinesis

Alternative splicing

named isoforms=3

Expression

• isoform 1 & isoform 2 are expressed in testis
• elevated expression in a subset of cancer cells such as hepG2, HuH7 & HeLa cells
• expression is maximum at M phase

Pathology

• defects in AURKC are the cause of infertility with multi-tailed spermatozoa & excessive DNA

More general terms

• aurora kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6795
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6795
• OMIM: https://mirror.omim.org/entry/243060
• OMIM: https://mirror.omim.org/entry/603495
• UniProt: http://www.uniprot.org/uniprot/Q9UQB9.html