mineralocorticoid receptor; MR; nuclear receptor subfamily 3 group C member 2 (NR3C2, MCR, MLR)
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Function
- receptor for both mineralocorticoids & glucocorticoids
- binds to mineralocorticoid response elements (MRE) & transactivates target genes
- effect is to increase ion & water transport & thus raise extracellular fluid volume & blood pressure & lower K+ levels
- cytoplasmic anchoring &/or assembly;
- may interact with HSD11B2 in the absence of ligand.
- binds the coactivators NCOA1, NCOA2, TIF1 & NRIP1
- phosphorylated
Structure
- composed of three domains:
- modulating N-terminal domain
- DNA-binding domain
- C-terminal steroid-binding domain
- belongs to the nuclear hormone receptor family, NR3 subfamily
- contains 1 nuclear receptor DNA-binding domain
Compartment
- cytoplasm, nucleus, endoplasmic reticulum membrane
- cytoplasmic & nuclear in the absence of ligand
- nuclear after ligand-binding
- when bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane
Alternative splicing
named isoforms=4
Additional isoforms seem to exist
Expression
- ubiquitous
- highly expressed in distal tubules, convoluted tubules & cortical collecting duct in kidney, & in sweat glands
- detected at lower levels in cardiomyocytes, in epidermis & in colon enterocytes
Pathology
- defects in NR3C2 are a cause of
- autosomal dominant pseudohypoaldosteronism type 1
- early onset hypertension with severe exacerbation in pregnancy
Comparative biology
- type I corticosteroid receptor (rat).
More general terms
Additional terms
References
- ↑ Alberts et al Molecular Biology of the Cell, 2nd ed. 1989, pg 704
- ↑ Journal Watch 20(16):130, 2000 Geller DS et al Science 289:119, 2000
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=NR3C2
- ↑ Wikipedia; Note: mineralocorticoid receptor entry http://en.wikipedia.org/wiki/mineralocorticoid_receptor
- ↑ UniProt http://www.uniprot.org/uniprot/P08235.html