mineralocorticoid receptor activation

Pathology

• mineralocorticoid receptor activation by sterois including progesterone

Genetics

• mutation in gene for mineralocorticoid receptor

Clinical manifestations

• hypertension at young age
• exacerbation during pregnancy

Laboratory

• plasma renin: low
• serum aldosterone: low

Management

• thiazide diuretics

More general terms

• genetic disease of the endocrine system

Additional terms

• mineralocorticoid receptor; MR; nuclear receptor subfamily 3 group C member 2 (NR3C2, MCR, MLR)