renin in plasma

Indications

• screening for primary hyperaldosteronism in conjunction with plasma aldosterone

Contraindications

• do not use to stratify patients with hypertension
• do nor use to predict response to specific antihypertensives

Test interactions

• decreases (false positives for primary hyperaldosteronism)
  • alpha-adrenergic receptor agonists
  • beta-adrenergic receptor antagonists
  • direct renin inhibitors
  • NSAIDs
• increases (false negatives for primary hyperaldosteronism)
  • ACE inhibitors
  • dihydropyridine calcium channel blocker
  • diuretic
  • mineralocorticoid receptor antagonists

Reference interval

• 3.3-41 UIU/mL
• 0.2-3.2 ng/mL/hour
• 2.9-24 ng/mL/hour [5

* 11.2 UIU/mL per ng/(mL*hour)

Increases

• Addison's disease
• cirrhosis
• hypertension
  • essential hypertension
  • renovascular hypertension
  • malignant hypertension
• ACE inhibitors, ARBs
• hemorrhage
• hypokalemia
• renin-producing neoplasm

Decreases

• vasopressin therapy
• salt-retaining steroid therapy
• salt-sensitive essential hypertension
• primary hyperaldosteronism

More general terms

• special chemistry test

More specific terms

• renin in plasma supine
• renin in plasma upright

Additional terms

• prorenin in plasma
• renin; angiotensinogenase (REN)

Component of

• captopril-renin stimulation test
• angiotensin-1/renin activity in plasma
• Aldosterone/Renin in serum/plasma
• aldosterone+ renin panel in/plasma
• intravenous salt loading test
• fludrocortisone suppression test