Aldosterone/Renin in serum/plasma
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Indications
Test interactions
- increases (false positives for primary hyperaldosteronism)
- decreases (false negatives for primary hyperaldosteronism)
Clinical significance
- initial screening for primary hyperaldosteronism consists of midmorning ambulatory plasma renin + plasma aldosterone in a normovolemic, normokalemic patient
- screening positive if plasma aldosterone > 15 ng/dL, or
- plasma aldosterone/renin activity ratio
| ratio | aldosterone | renin -> angiotensin-1 |
|---|---|---|
| > 23 | ng/dL | ng/mL/hr (positive) |
| > 23 | ng/dL | ng/mL/hr sensitivity of 97%, specificity of 94% |
| > 67 | ng/dL | ng/mL/hr sensitivity of 100% |
* sensitivity for primary aldosteronism ranges from 10% to 100%
* specificity ranges from 70% to 100%[3]
More general terms
Additional terms
- aldosterone (Electrocortin, Aldocortin)
- angiotensin-1/renin activity in plasma
- renin; angiotensinogenase (REN)
Components
References
- ↑ Panel of 3 tests Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0070073.jsp
- ↑ 2.0 2.1 Medical Knowledge Self Assessment Program (MKSAP) 16, 17, 18. American College of Physicians, Philadelphia 2012, 2015, 2018
- ↑ 3.0 3.1 Hung A, Ahmed S, Gupta A et al. Performance of the aldosterone to renin ratio as a screening test for primary aldosteronism. J Clin Endocrinol Metab 2021 Aug; 106:2423. PMID: https://www.ncbi.nlm.nih.gov/pubmed/34008000 https://academic.oup.com/jcem/article-abstract/106/8/2423/6278133